Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine

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Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine.

A large surface area and continuous exposure to the outside environment through food intake make the intestines an ideal location for the growth and/or entry of pathogenic microorganisms and parasites. It is therefore not surprising that large numbers of lymphocytes are associated with the intestines within specialized gut-associated lymphoid tissues (GALT) and in the intestines themselves (1)....

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Activation of CCR9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine.

PURPOSE Specific chemokines and their respective receptors have been implicated in distant tumor cell metastasis. Cutaneous melanoma has a distinct pattern of metastasis, preferentially targeting the submucosa of the small intestine. However, the underlying pathogenic mechanism remains unknown. Migration of CCR9(+) lymphocytes to the small intestine is known to occur in response to the chemoatt...

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CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

The intestinal mucosa is continually exposed to a large array of foreign antigens and must respond appropriately to maintain mucosal integrity while at the same time mounting effective immune responses to potential pathogens. The recruitment of T lymphocytes to intestinal effector sites is thought to play a critical role in this process. Following activation in secondary lymphoid organs, T lymp...

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Lymphocyte Differentiation and Effector Functions

Lymphocytes are essential in combating infections; they display powerful effector mechanisms and their activity must be regulated at all times to avoid self-tissue or cells destruction. These immunological lineages are detected in protochordates and vertebrates. Long-term hematopoietic cells originate, in the bone marrow, all hematopoietic lineages, including lymphocytes. B and T lymphocytes ar...

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CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa.

The recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central to the development of an effective mucosal immune response, yet the mechanism by which this process occurs remains to be fully defined. Here we show that the CC chemokine receptor 9 (CCR9) is selectively and functionally expressed on murine alpha(E)beta(7)(+) naive CD8alphabeta(+) lymphocytes and a subset of r...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2002

ISSN: 0021-9738

DOI: 10.1172/jci0216946